Cancer Epigenetics Group
The Sproul group seeks to understand the role of epigenetics in human disease, particularly focusing on DNA methylation alterations in breast cancer. The key questions in the lab are:
1. What are the molecular mechanisms underpinning the reprogramming of DNA methylation in breast cancer?
2. How does this dysfunction impact on cancer risk and pathogenesis?
Our research focuses on understanding these questions using an interdisciplinary combination of computational and laboratory biology. We apply machine-learning techniques to define molecular epigenomic signatures in patient cohorts and dissect the mechanisms underpinning these signatures using genome-editing techniques in experimental models. While we principally work on DNA methylation in breast cancer, we also collaborate with other groups to understand the role of epigenetics in human disease much more widely.