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Ghazal Pathway Informatics Group

We are primarily concerned with pathway analysis and transcriptional profiling. We have studied a range of systems including cholesterol metabolism, microRNA regulation, TNF regulation and interferon signalling at transcriptional, proteomic and flux levels. In particular, we have comprehensively mapped out and modelled the structure and composition of a number of critical immune pathways to new levels of detail. developed software tools to analyse the whole cell responses to infection, developed databases making available large transcriptional profiling datasets, built software libraries to facilitate the use of high performance computing tools in statistical analysis.