The Evolutionary Genetics and Genomics group works to understand the processes of selection and mutation that are acting to shape genomes. It is well known that selection shapes the pattern of genomic changes that accumulate as populations diverge from a common ancestor, but it is becoming increasingly clear that variation in the pattern of new mutations can also generate superficially similar signals. Improved separation of these confounding evolutionary signatures is crucial if we are to understand how organisms evolve, and to relate contemporary genetic changes to human biology and disease.
We are particularly interested in the genetic changes that alter the expression of genes and the selective forces that drive the development and progression of cancer.
The frequent evolutionary birth and death of functional promoters in mouse and human.
Young RS, Hayashizaki Y, Andersson R, Sandelin A, Kawaji H, Itoh M, Lassmann T, Carninci P, FANTOM Consortium, Bickmore WA, Forrest AR, Taylor MS.
Genome Research 2015 doi:10.1101/gr.190546.115 [PMID:26228054]
Quantifying single nucleotide variant detection sensitivity in exome sequencing.
Meynert AM, Bicknell LS, Hurles ME, Jackson AP, Taylor MS.
BMC Bioinformatics 2013 doi:10.1186/1471-2105-14-195 [PMID:23773188]