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Taylor Group

The Evolutionary Genetics and Genomics group works to understand the processes of selection and mutation that are acting to shape genomes. It is well known that selection shapes the pattern of genomic changes that accumulate as populations diverge from a common ancestor, but it is becoming increasingly clear that variation in the pattern of new mutations can also generate superficially similar signals. Improved separation of these confounding evolutionary signatures is crucial if we are to understand how organisms evolve, and to relate contemporary genetic changes to human biology and disease.

We are particularly interested in the genetic changes that alter the expression of genes and the selective forces that drive the development and progression of cancer.

Key publications

The frequent evolutionary birth and death of functional promoters in mouse and human.
Young RS, Hayashizaki Y, Andersson R, Sandelin A, Kawaji H, Itoh M, Lassmann T, Carninci P, FANTOM Consortium, Bickmore WA, Forrest AR, Taylor MS.
Genome Research 2015 doi:10.1101/gr.190546.115 [PMID:26228054

Lagging-strand replication shapes the mutational landscape of the genome.
Reijns MA, Kemp H, Ding J, de Proce SM, Jackson AP, Taylor MS.
Nature 2015 doi:10.1038/nature14183 [PMID:25624100]

Variant detection sensitivity and biases in whole genome and exome sequencing.
Meynert AM, Ansari M, FitzPatrick DR, Taylor MS.
BMC Bioinformatics 2014 doi:10.1186/1471-2105-15-247 [PMID:25038816]

A promoter-level mammalian expression atlas.
FANTOM Consortium.
Nature 2014 doi:10.1038/nature13182 [PMID:24670764]

Quantifying single nucleotide variant detection sensitivity in exome sequencing.
Meynert AM, Bicknell LS, Hurles ME, Jackson AP, Taylor MS.
BMC Bioinformatics 2013 doi:10.1186/1471-2105-14-195 [PMID:23773188]

Molecular biology. The structure of change.
Semple CA, Taylor MS.
Science 2009 doi:10.1126/science.1169408 [PMID:19150834]

Rapidly evolving human promoter regions.
Taylor MS, Massingham T, Hayashizaki Y, Carninci P, Goldman N, Semple CA.
Nature Genetics 2008 doi:10.1038/ng1108-1262 [PMID:18957975]

Heterotachy in mammalian promoter evolution.
Taylor MS, Kai C, Kawai J, Carninci P, Hayashizaki Y, Semple CA.
PLoS Genetics 2006 doi:10.1371/journal.pgen.0020030 [PMID:16683025]