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Description: The official database of the International Union of Basic and Clinical Pharmacology (IUPHAR) Committee on Receptor Nomenclature and Drug Classification (NC-IUPHAR). NC-IUPHAR coordinates an international network of expert scientists providing curated information distilled from primary literature sources. IUPHAR-DB provides detailed information on the pharmacological, functional and (patho)physiological properties of biological targets including G protein-coupled receptors, voltage-and ligand-gated ion channels, nuclear receptors and enzymes and their interactions with natural and synthetic ligands.